Long QT Syndrome (LQTS)

Long QT Syndrome (LQTS) is a condition affecting the heart's electrical system, which can lead to irregular heartbeats (arrhythmias) and can be potentially life-threatening. It's named for the prolonged interval it causes in the heart's electrical cycle, specifically in the QT interval seen on an electrocardiogram (ECG or EKG). Here are the aspects of LQTS:

Causes

  1. Genetic: Most cases are inherited and are due to mutations in genes that control heart cell proteins called ion channels. These mutations disrupt the normal flow of ions, prolonging the QT interval.

  2. Medications: Certain medications can prolong the QT interval and induce LQTS. These include some antibiotics, antidepressants, antihistamines, and others known to affect heart rhythm.

  3. Other factors: Low levels of potassium, calcium, or magnesium in the blood can lead to LQTS. Stress and exercise can also trigger arrhythmias in people with the condition.

Symptoms

  1. Fainting (Syncope): Sudden fainting spells or seizures due to irregular heartbeats are common symptoms.

  2. Seizures: Sometimes, what appears to be a seizure may actually be a fainting spell due to LQTS.

  3. Sudden Cardiac Arrest: In severe cases, LQTS can lead to sudden, unexpected cardiac arrest or death.

Treatment

  1. Beta-Blockers: Medications that help manage heart rate and prevent sudden spikes in heart activity.

  2. Potassium Supplements: If the LQTS is due to low potassium, supplements might be prescribed.

  3. Implantable Devices: Devices like pacemakers or implantable cardioverter-defibrillators (ICDs) might be necessary for severe cases to monitor and stabilize heart rhythm.

  4. Surgery: In some cases, surgery to modify the electrical pathways in the heart may be recommended.

  5. Lifestyle Changes: Avoiding strenuous exercise, stress, and medications known to affect heart rhythm can help manage symptoms.

Management and Living with LQTS

Individuals with LQTS need to be careful about drug intake and should be monitored regularly for any changes in heart rhythm. Family members might also be advised to get genetic screening if the condition is inherited. Active management and awareness of triggers are crucial for those with LQTS to lead a normal life.

Understanding and managing LQTS is critical due to its potentially life-threatening consequences. If someone exhibits symptoms or has a family history of the condition, it's important to seek medical attention for proper diagnosis and treatment planning.



Long QT Syndrome: Mayo Clinic Radio

Dr. Michael Ackerman, a pediatric cardiologist at Mayo Clinic, explains the heart rhythm condition known as long QT syndrome. This interview originally aired Sept. 16, 2017.